Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

During an inflammatory process, shift in the cellular metabolism associated with an increase
in extracellular acidification are well-known features. This pH drop in the inflamed tissue is …

Catalytic anticancer metallodrugs active at low doses could minimize side-effects, introduce
novel mechanisms of action that combat resistance and widen the spectrum of anticancer …

Lactate, the end product of glycolysis, efficiently functions as the carbon source, signaling
molecules and immune regulators. Lactylation, being regulated by lactate, has recently been …

GPR81 is a G-protein coupled receptor (GPCR) discovered in 2001, but deorphanized only
7 years later, when its affinity for lactate as an endogenous ligand was demonstrated. More …

Research to date has provided novel insights into lactate's positive role in multiple brain
functions and several brain diseases. Although notable controversies and discrepancies …

Objective To review the current literature with respect to the physiology, pathophysiology,
and measurement of lactate. Data Sources Data were sourced from veterinary and human …

The platelet is considered as an accessible and valuable tool to study mitochondrial
function, owing to its greater content of fully functional mitochondria compared with other …

In contrast to L-lactate, D-lactate is produced in minimal quantities by human cells, and the
plasma D-lactate concentration normally is maintained at a concentration of only about 0.01 …

New evidence shows that host-microbiota crosstalk can be modulated via endogenous
miRNAs. We have previously reported that miR-21 ablation protects against liver injury in …