Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …

Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …

Data independent acquisition (DIA) mass spectrometry is a powerful technique that is
improving the reproducibility and throughput of proteomics studies. Here, we introduce an …

To the Editor: Analysis of raw reads from RNA sequencing (RNA-seq) makes it possible to
reconstruct complete gene structures, including multiple splice variants, without relying on …

A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no …

Abstract TH17 cells (interleukin-17 (IL-17)-producing helper T cells) are highly
proinflammatory cells that are critical for clearing extracellular pathogens and for inducing …

Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was
recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry …

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

Despite their importance, the molecular circuits that control the differentiation of naive T cells
remain largely unknown. Recent studies that reconstructed regulatory networks in …

Genome biology approaches have made enormous contributions to our understanding of
biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins …