Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

How metabolism is reprogrammed during neuronal differentiation is unknown. We found that
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …

In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide.
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …

Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal
development, survival, and function in the central nervous system (CNS), being implicated in …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …