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The development and improvement of immunodeficient mice and humanized immune system mouse models
J Chen, S Liao, Z **ao, Q Pan, X Wang… - Frontiers in …, 2022 - frontiersin.org
Animal models play an indispensable role in the study of human diseases. However, animal
models of different diseases do not fully mimic the complex internal environment of humans …
models of different diseases do not fully mimic the complex internal environment of humans …
The challenge of viral reservoirs in HIV-1 infection
▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a
replication-competent form of the virus accumulates and persists with more stable kinetic …
replication-competent form of the virus accumulates and persists with more stable kinetic …
[HTML][HTML] Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
HIV-1 Tat transactivation is vital for completion of the viral life cycle and has been implicated
in determining proviral latency. We present an extensive experimental/computational study …
in determining proviral latency. We present an extensive experimental/computational study …
[كتاب][B] HIV and the pathogenesis of AIDS.
JA Levy - 1994 - cabidigitallibrary.org
This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …
has been updated and expanded-now citing more than 2100 references (100 pages of the …
T cell dynamics in HIV-1 infection
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …
infection of the human immune system that invariably, over the course of years, leads to its …
HIV-1 transcription and latency: an update
C Van Lint, S Bouchat, A Marcello - Retrovirology, 2013 - Springer
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
Targeting type I interferon–mediated activation restores immune function in chronic HIV infection
Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis
Identification of T-cell subsets that are infected in vivo is essential to understanding the
pathogenesis of human immunodeficiency virus (HIV) disease; however, this goal has been …
pathogenesis of human immunodeficiency virus (HIV) disease; however, this goal has been …
The CCR5 and CXCR4 coreceptors—central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection
JP Moore, SG Kitchen, P Pugach… - AIDS research and human …, 2004 - liebertpub.com
In this review, we will discuss what is known, what is suspected, and what still remains
obscure about the central role played by coreceptor expression and usage in the …
obscure about the central role played by coreceptor expression and usage in the …
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
The use of antiretroviral therapy in HIV type 1 (HIV-1)–infected patients does not lead to
virus eradication. This is due, to a significant degree, to the fact that HIV-1 can establish a …
virus eradication. This is due, to a significant degree, to the fact that HIV-1 can establish a …