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Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Multicomponent reactions as a potent tool for the synthesis of benzodiazepines
Benzodiazepines (BZDs), a diverse class of benzofused seven-membered N-heterocycles,
display essential pharmacological properties and play vital roles in some biochemical …
display essential pharmacological properties and play vital roles in some biochemical …
Immobilized nickel boride nanoparticles on magnetic functionalized multi-walled carbon nanotubes: a new nanocomposite for the efficient one-pot synthesis of 1, 4 …
In this study, a new magnetic nanocomposite consisting of Ni2B nanoparticles anchored on
magnetic functionalized multi-walled carbon nanotubes (Fe3O4/f-MWCNT/Ni2B) was …
magnetic functionalized multi-walled carbon nanotubes (Fe3O4/f-MWCNT/Ni2B) was …
Multicomponent DNA-compatible synthesis of an annelated benzodiazepine scaffold for focused chemical libraries
G Zhao, H Wang, J Luo, X He, F **ong, Y Li… - Organic …, 2023 - ACS Publications
Annelated benzodiazepines are attractive drug-like scaffolds with a broad spectrum of
biological activities. Incorporation of this heterocyclic core into DNA-encoded chemical …
biological activities. Incorporation of this heterocyclic core into DNA-encoded chemical …
Synthesis of functionalized chromene and spirochromenes using l-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature
An efficient and recyclable homogeneous catalyst is developed using commercially cheap l-
proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) …
proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) …
Bio-fabrication of silver-silver chloride nanoparticles using Annona muricata leaf extract: characterization, biological, dye degradation and eco-toxicity studies
This work reports the bio-fabrication of silver-silver chloride nanoparticles by using aqueous
Annona muricata leaf extract. Using UV–visible spectrophotometer, the presence of …
Annona muricata leaf extract. Using UV–visible spectrophotometer, the presence of …
A facile and efficient multicomponent ultrasound-assisted “on water” synthesis of benzodiazepine ring
A facile and efficient multicomponent synthesis of benzodiazepine ring in water under
ultrasound irradiation is reported first time. The current procedure escapes traditional …
ultrasound irradiation is reported first time. The current procedure escapes traditional …
Naphthoquinone fused diazepines targeting hyperamylasemia: potential therapeutic agents for diabetes and cancer
Aim: Elevated levels of amylase in the blood, known as hyperamylasemia, have been
correlated with diabetes and cancer. To investigate the impact of hyperamylasemia on …
correlated with diabetes and cancer. To investigate the impact of hyperamylasemia on …
Sulfonic acid functionalized covalent organic frameworks as efficient catalyst for the one-pot tandem reactions
K Gong, C Li, D Zhang, H Lu, Y Wang, H Li, H Zhang - Molecular Catalysis, 2022 - Elsevier
A covalent organic framework containing hydroxyl groups (HO-COF) has been predesigned
and synthesized by the cyclotrimerization reaction of acetyls, which was used as a pre …
and synthesized by the cyclotrimerization reaction of acetyls, which was used as a pre …
Synthesis of 2-styryl-quinazoline and 3-styryl-quinoxaline based sulfonate esters via sp 3 C–H activation and their evaluation for α-glucosidase inhibition
Synthesis of 2-styryl-quinazolines and 3-styryl-quinoxaline based sulfonates is reported via
sp3 C–H functionalization in the presence of triethylamine (10 mol%). The resulting …
sp3 C–H functionalization in the presence of triethylamine (10 mol%). The resulting …