Parkinson's disease (PD) is one of the most common neurodegenerative disorders with a
global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both …

Parkinson's disease (PD) is usually diagnosed through motor symptoms that make the
patient incapable of carrying out daily activities; however, numerous non-motor symptoms …

Cellular communication linking microglia activation and dopaminergic neuronal loss play an
imperative role in the progression of Parkinson's disease (PD); however, underlying …

Microglia-mediated inflammation plays an important role in the pathogenesis of several
neurodegenerative diseases including Parkinson's disease (PD). Recently, autophagy has …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

The microtubule-associated protein tau has risk alleles for both Alzheimer's disease and
Parkinson's disease and mutations that cause brain degenerative diseases termed …

Neurological disorders can be modeled in animals so as to recreate specific pathogenic
events and behavioral outcomes. Parkinson's Disease (PD) is the second most common …

Animal experimentation in the Parkinson's disease (PD) field is a classic example of how the
use of animal models to study diseases can have a significant impact on human health …

Parkinson's disease (PD) is a neurological movement disorder primarily resulting from
damage to the nigrostriatal dopaminergic pathway. To elucidate the pathogenesis …

The rotarod test is widely used to evaluate the motor coordination of rodents, and is
especially sensitive in detecting cerebellar dysfunction. However, mice with striatal …