The initiation and execution of cell death can be regulated by various lipids. How the levels
of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We …

Drug combination therapy is a promising strategy to treat complex diseases such as cancer
and infectious diseases. However, current knowledge of drug combination therapies …

Cellular growth and the preparation of cells for division between two successive cell
divisions is called the cell cycle. The cell cycle is divided into several phases; the length of …

How cancer cells respond to nutrient deprivation remains poorly understood. In certain
cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell …

Dietary lipids impact development, homeostasis, and disease, but links between specific
dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of …

Ferroptosis is a regulated form of cell death associated with the iron-dependent
accumulation of phospholipid hydroperoxides. Inducing ferroptosis is a promising approach …

Ferroptosis is a non-apoptotic form of cell death that can be triggered by inhibiting the
system xc− cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione …

Ferroptosis is an oxidative form of nonapoptotic cell death whose transcriptional regulation
is poorly understood. Cap'n'collar (CNC) transcription factors including nuclear factor …

Cell death can be executed by regulated apoptotic and nonapoptotic pathways, including
the iron-dependent process of ferroptosis. Small molecules are essential tools for studying …

Drug combination therapy has the potential to enhance efficacy, reduce dose-dependent
toxicity and prevent the emergence of drug resistance. However, discovery of synergistic …