Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …
field has experienced an exponential growth since early 2000's. The path to the …
SELEX: Critical factors and optimization strategies for successful aptamer selection
Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
Deciphering eukaryotic gene-regulatory logic with 100 million random promoters
How transcription factors (TFs) interpret cis-regulatory DNA sequence to control gene
expression remains unclear, largely because past studies using native and engineered …
expression remains unclear, largely because past studies using native and engineered …
[HTML][HTML] DNA-binding specificities of human transcription factors
Although the proteins that read the gene regulatory code, transcription factors (TFs), have
been largely identified, it is not well known which sequences TFs can recognize. We have …
been largely identified, it is not well known which sequences TFs can recognize. We have …
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
C Tuerk, L Gold - science, 1990 - science.org
High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on
alternate cycles of ligand selection from pools of variant sequences and amplification of the …
alternate cycles of ligand selection from pools of variant sequences and amplification of the …
On the immortality of television sets:“function” in the human genome according to the evolution-free gospel of ENCODE
A recent slew of ENCyclopedia Of DNA Elements (ENCODE) Consortium publications,
specifically the article signed by all Consortium members, put forward the idea that more …
specifically the article signed by all Consortium members, put forward the idea that more …
[HTML][HTML] Genome-wide map of nucleosome acetylation and methylation in yeast
Eukaryotic genomes are packaged into nucleosomes whose position and chemical
modification state can profoundly influence regulation of gene expression. We profiled …
modification state can profoundly influence regulation of gene expression. We profiled …
The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α helices: crystal structure of the protein-DNA complex
The yeast transcriptional activator GCN4 is 1 of over 30 identified eukaryotic proteins
containing the basic region leucine zipper (bZIP) DNA-binding motif. We have determined …
containing the basic region leucine zipper (bZIP) DNA-binding motif. We have determined …
Human Smad3 and Smad4 are sequence-specific transcription activators
Mounting evidence indicates that Smad proteins are required for TGFβ signaling, but the
way (s) in which Smad proteins propagate this signal is unclear. We found that two human …
way (s) in which Smad proteins propagate this signal is unclear. We found that two human …
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities
Transcription factors (TFs) interact with specific DNA regulatory sequences to control gene
expression throughout myriad cellular processes. However, the DNA binding specificities of …
expression throughout myriad cellular processes. However, the DNA binding specificities of …