By exerting pro-and anti-tumorigenic actions, tumor-infiltrating immune cells can profoundly
influence tumor progression, as well as the success of anti-cancer therapies. Therefore, the …

Gene expression analyses of bulk tissues often ignore cell type composition as an important
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …

Many computational methods have been developed to infer cell type proportions from bulk
transcriptomics data. However, an evaluation of the impact of data transformation, pre …

We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from
bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor …

In metastatic cancer, the degree of heterogeneity of the tumor microenvironment (TME) and
its molecular underpinnings remain largely unstudied. To characterize the tumor–immune …

Various computational approaches have been developed for estimating the relative
abundance of different cell types in the tumor microenvironment (TME) using bulk tumor …

Bulk tissue DNA methylation profiling has been used to examine epigenetic mechanisms
and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular …

Immune‐related toxicities, otherwise known as immune‐related adverse events (irAEs),
occur in a substantial fraction of cancer patients treated with immune checkpoint inhibitors …

The prognostic value of immune cell infiltration within the tumor microenvironment (TME)
has been extensively investigated via histological and genomic approaches. Based on the …

The clinical risk stratification of diffuse large B-cell lymphoma (DLBCL) relies on the
International Prognostic Index (IPI) for the identification of high-risk disease. Recent studies …