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Current status of N-, O-, S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview
Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
Exploring fluorine-substituted piperidines as potential therapeutics for diabetes mellitus and Alzheimer's diseases
In the current study, a series of fluorine-substituted piperidine derivatives (1–8) has been
synthesized and characterized by various spectroscopic techniques. In vitro and in vivo …
synthesized and characterized by various spectroscopic techniques. In vitro and in vivo …
[HTML][HTML] Synthesis of new bis (dimethylamino) benzophenone hydrazone for diabetic management: In-vitro and in-silico approach
Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
Novel hydrazones derived from anthranilic acid as potent cholinesterases and α‐glycosidase inhibitors: Synthesis, characterization, and biological effects
N‐substitued anthranilic acid derivatives are commonly found in the structure of many
biologically active molecules. In this study, new members of hydrazones derived from …
biologically active molecules. In this study, new members of hydrazones derived from …
Design and synthesis of 2-amino-4,6-diarylpyrimidine derivatives as potent α-glucosidase and α-amylase inhibitors: structure–activity relationship, in vitro, QSAR …
In the present study, a series of 2-amino-4, 6-diarylpyrimidine derivatives was designed,
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
Synthesis, in vitro α-glucosidase, and acetylcholinesterase inhibitory activities of novel indol-fused pyrano [2, 3-d] pyrimidine compounds
In this study, new indol-fused pyrano [2, 3-d] pyrimidines were designed and synthesized.
These products were obtained in moderate to good yields and their structures were …
These products were obtained in moderate to good yields and their structures were …
Synthesis, in vitro β-glucuronidase inhibitory potential and molecular docking study of benzimidazole analogues
We have synthesized fifteen benzimidazole bearing Schiff base analogues (1–15),
characterized through different techniques such as NMR, HR-EIMS and evaluated against β …
characterized through different techniques such as NMR, HR-EIMS and evaluated against β …
Synthesis of zinc phthalocyanine containing 1, 2-phenylene bis (3-chloropropanoate) substituted groups and investigation of their metabolic enzyme inhibitory effects
Abstract In this study, 4, 5-dicyano-1, 2-phenylene dinicotinate compound was obtained as a
result of the reaction of 4, 5-dichlorophthalonitrile and nicotinic acid. This compound was …
result of the reaction of 4, 5-dichlorophthalonitrile and nicotinic acid. This compound was …
Synthesis, in vitro α-glucosidase and α-amylase activities, and an in silico molecular docking study of triazinoindole-thiazolidinone hybrid derivatives
Abstract Triazinoindole-thiazolidinone hybrid derivatives (1–10) was synthesised and
evaluated them against α-glucosidase and α-amylase enzymes. All synthesised derivatives …
evaluated them against α-glucosidase and α-amylase enzymes. All synthesised derivatives …