The new techniques of genome context analysis—chromosomal gene clustering, protein
fusions, occurrence profiles and shared regulatory sites—infer functional coupling between …

The gap between the amount of genome information released by genome sequencing
projects and our knowledge about the proteins' functions is rapidly increasing. To fill this …

Metabolic pathways have traditionally been described in terms of biochemical reactions and
metabolites. With the use of structural genomics and systems biology, we generated a three …

Thymidylate synthase (TS) enzymes catalyse the biosynthesis of deoxythymidine
monophosphate (dTMP or thymidylate), and so are important for DNA replication and repair …

ABSTRACT A virus infecting the hyperthermophilic archaeon Sulfolobus tengchongensis
has been isolated from a field sample from Tengchong, China, and characterized. The virus …

While nucleic acid-targeting effectors are known to be central to biological conflicts and anti-
selfish element immunity, recent findings have revealed immune effectors that target their …

Reduced folate derivatives participate in numerous reactions of bacterial intermediary
metabolism. Consequently, the well-characterized enzyme implicated in the formation of …

Like thymidylate synthase (TS) in eukaryotes, the thymidylate synthase-complementing
proteins (TSCPs) are mandatory for cell survival of many prokaryotes in the absence of …

Sequence analysis of the 330-kb double-stranded DNA genome of Paramecium bursaria
chlorella virus-1 revealed an open reading frame A674R that encodes a protein with up to …

A novel flavin-dependent thymidylate synthase was identified recently as an essential gene
in many archaebacteria and some pathogenic eubacteria. This enzyme, ThyX, is a potential …