Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that'walls off'the infecting …

Leprosy, a chronic human neurological disease, results from infection with the obligate
intracellular pathogen Mycobacterium leprae, a close relative of the tubercle bacillus …

Despite the importance of tuberculosis as a public health problem, we know relatively little
about the molecular mechanisms used by the causative organism, Mycobacterium …

Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

M. tuberculosis and M. leprae are considered to be prototypical intracellular pathogens that
have evolved strategies to enable growth in the intracellular phagosomes. In contrast, we …

Biochemical, serological and microbiological methods have been used to dissect pathogens
and identify the components useful for vaccine development. Although successful in many …

Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

Tuberculosis poses a significant threat to mankind. Multidrug-resistant strains are on the
rise, and Mycobacterium tuberculosis infection is often associated with human …