Analytical methods in untargeted metabolomics: state of the art in 2015
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …
molecule composition of biofluids and tissues, and is actually one of the most rapidly …
Precision medicine in complex diseases—Molecular subgrou** for improved prediction and treatment stratification
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …
factors and comprise common noncommunicable diseases, including allergies …
[HTML][HTML] HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
[HTML][HTML] Lipidomics: new tools and applications
MR Wenk - Cell, 2010 - cell.com
Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as
bystanders in the drama of biological systems. The emerging field of lipidomics is driven by …
bystanders in the drama of biological systems. The emerging field of lipidomics is driven by …
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
L Ottensmann, R Tabassum, SE Ruotsalainen… - Nature …, 2023 - nature.com
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …
lipid-associated variants and understand the link between lipid species and cardiometabolic …
A genome-wide association study of the human metabolome in a community-based cohort
Because metabolites are hypothesized to play key roles as markers and effectors of
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …
Discovery of sexual dimorphisms in metabolic and genetic biomarkers
Metabolomic profiling and the integration of whole-genome genetic association data has
proven to be a powerful tool to comprehensively explore gene regulatory networks and to …
proven to be a powerful tool to comprehensively explore gene regulatory networks and to …
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Understanding genetic architecture of plasma lipidome could provide better insights into
lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome …
lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome …
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
Metabolites are small molecules involved in cellular metabolism, which can be detected in
biological samples using metabolomic techniques. Here we present the results of genome …
biological samples using metabolomic techniques. Here we present the results of genome …