The liver is a very complex organ that ensures numerous functions; it is thus susceptible to
multiple types of damage and dysfunction. Since 1983, orthotopic liver transplantation (OLT) …

Micro and small bioreactors are well described for use in bioprocess development in pre-
production manufacture, using ultra-scale down and microfluidic methodology. However, the …

BACKGROUND Acute liver failure (ALF) has a high mortality varying from 80% to 85% with
rapid progress in multi-organ system failure. Bioartificial liver (BAL) support systems have …

Over the past few decades, the use of cell microencapsulation technology has been
promoted for a wide range of applications as sustained drug delivery systems or as cells …

Liver transplantation is currently the only curative treatment for several liver diseases such
as acute liver failure, end‐stage liver disorders, primary liver cancers, and certain genetic …

Liver diseases contribute markedly to the global burden of mortality and disease. The limited
organ disposal for orthotopic liver transplantation results in a continuing need for alternative …

Objective Our objective was to compare the effectiveness of nonbiological artificial liver
(NBAL) support, particularly short-term (28-day) survival rates, in patients who underwent …

Liver failure is a lethal condition with hepatocellular dysfunction, and liver transplantation is
presently the only effective treatment. However, due to the limited availability of donors and …

For patients with severe kidney or liver failure the best solution is currently organ
transplantation. However, not all patients are eligible for transplantation and due to limited …

Acute liver failure (ALF) is a rapidly progressive disease with high morbidity and mortality
rates. Liver transplantation and artificial liver (AL) support systems, such as ALs and …