Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Several non-redundant features of the tumour microenvironment facilitate
immunosuppression and limit anticancer immune responses. These include physical …

High iron is a risk factor for type 2 diabetes mellitus (T2DM) and affects most of its cardinal
features: decreased insulin secretion, insulin resistance, and increased hepatic …

Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to
ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is …

There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …