Triple threat: how diabetes results in worsened bacterial infections

BP Darwitz, CJ Genito, LR Thurlow - Infection and Immunity, 2024 - journals.asm.org
Diabetes mellitus, characterized by impaired insulin signaling, is associated with increased
incidence and severity of infections. Various diabetes-related complications contribute to …

Interspecies Interactions within the Host: the Social Network of Group B Streptococcus

ME Mejia, CM Robertson, KA Patras - Infection and immunity, 2023 - journals.asm.org
ABSTRACT Group B Streptococcus (GBS) is a pervasive neonatal pathogen accounting for
a combined half a million deaths and stillbirths annually. The most common source of fetal or …

Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract

BL Spencer, AM Job, CM Robertson… - Molecular …, 2023 - Wiley Online Library
Type VIIb secretion systems (T7SSb) in Gram‐positive bacteria facilitate physiology,
interbacterial competition, and/or virulence via EssC ATPase‐driven secretion of small ɑ …

The SaeRS two-component system regulates virulence gene expression in group B Streptococcus during invasive infection

F Coppolino, GV De Gaetano, C Claverie, O Sismeiro… - MBio, 2024 - journals.asm.org
ABSTRACT Group B Streptococcus (GBS) is a pathobiont responsible for invasive infections
in neonates and the elderly. The transition from a commensal to an invasive pathogen relies …

The impact of nutritional immunity on Group B streptococcal pathogenesis during wound infection

MS Akbari, RA Keogh, JN Radin, Y Sanchez-Rosario… - Mbio, 2023 - journals.asm.org
ABSTRACT Group B Streptococcus (GBS) is a Gram-positive pathobiont that can cause
adverse health outcomes in neonates and vulnerable adult populations. GBS is one of the …

Re-framing the importance of Group B Streptococcus as a gut-resident pathobiont

J Ling, AJ Hryckowian - Infection and Immunity, 2024 - journals.asm.org
ABSTRACT Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive
bacterial species that causes disease in humans across the lifespan. While antibiotics are …

Identification of a DNA-cytosine methyltransferase that impacts global transcription to promote group B streptococcal vaginal colonization

HS Manzer, T Brunetti, KS Doran - MBio, 2023 - journals.asm.org
ABSTRACT Group B Streptococcus (GBS) colonizes the female reproductive tract (FRT) and
causes adverse pregnancy outcomes and invasive disease following vertical transmission to …

Comparison of lateral tail vein and retro-orbital venous sinus as routes of inoculation to study Group B streptococcal systemic infection

J da Conceição Mendonça, S Lumsdaine… - Microbiology …, 2025 - journals.asm.org
Murine models are commonly used to understand pathogen and host determinants of
systemic infection. While these models have proven beneficial for uncovering bacterial …