Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

The genetics of obesity: from discovery to biology

RJF Loos, GSH Yeo - Nature Reviews Genetics, 2022 - nature.com
The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases

MR Corces, A Shcherbina, S Kundu, MJ Gloudemans… - Nature …, 2020 - nature.com
Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …

The Rotterdam Study: 2018 update on objectives, design and main results

MA Ikram, GGO Brusselle, SD Murad… - European journal of …, 2017 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology

J Plassais, J Kim, BW Davis, DM Karyadi… - Nature …, 2019 - nature.com
Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and
breed-associated behaviors resulting from human selective pressures. To identify the …

The Chicken Pan-Genome Reveals Gene Content Variation and a Promoter Region Deletion in IGF2BP1 Affecting Body Size

K Wang, H Hu, Y Tian, J Li, A Scheben… - Molecular biology …, 2021 - academic.oup.com
Domestication and breeding have reshaped the genomic architecture of chicken, but the
retention and loss of genomic elements during these evolutionary processes remain …

Heart disease and stroke statistics—2020 update: a report from the American Heart Association

SS Virani, A Alonso, EJ Benjamin, MS Bittencourt… - Circulation, 2020 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports on the most up-to-date statistics related to heart disease, stroke …

Heart disease and stroke statistics—2021 update: a report from the American Heart Association

SS Virani, A Alonso, HJ Aparicio, EJ Benjamin… - Circulation, 2021 - ahajournals.org
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease

E Marty, Y Liu, A Samuel, O Or, J Lane - Bone, 2017 - Elsevier
Sarcopenia is defined as an age associated decline in skeletal muscle mass. The
pathophysiology of sarcopenia is multifactorial, with decreased caloric intake, muscle fiber …

The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study

YF Pei, YZ Liu, XL Yang, H Zhang, GJ Feng… - Communications …, 2020 - nature.com
Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass
and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we …