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Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and …
Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …
Anti-cancer effects of polyphenols via targeting p53 signaling pathway: Updates and future directions
The anticancer effects of polyphenols are ascribed to several signaling pathways including
the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent …
the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent …
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …
genome integrity, including cell cycle control, DNA damage response, and apoptosis …
Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …
worldwide. Intracellular transduction pathways that end in the activation of specific …
The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases
M Li - Apoptosis, 2021 - Springer
P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …
Therapeutic benefits of flavonoids against neuroinflammation: a systematic review
Flavonoids are an important class of natural polyphenolic compounds reported to exert
beneficial effects in cardiovascular and metabolic diseases, cancer, autoimmune and …
beneficial effects in cardiovascular and metabolic diseases, cancer, autoimmune and …
Molecular crosstalk between cancer and neurodegenerative diseases
The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …
molecular determinants that are either complementarily deregulated, or share remarkably …
Biomarker profiling to determine clinical impact of microRNAs in cognitive disorders
W Zhai, M Zhao, C Wei, G Zhang, Y Qi, A Zhao… - Scientific Reports, 2024 - nature.com
Alzheimer's disease (AD) and post-stroke cognitive impairment (PSCI) are the leading
causes of progressive dementia related to neurodegenerative and cerebrovascular injuries …
causes of progressive dementia related to neurodegenerative and cerebrovascular injuries …