Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …

Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …

Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2
infection. However, it remains to be determined whether increased complement activation is …

Systemic candidiasis is a common, high-mortality, nosocomial fungal infection.
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …

Canonically, the complement system is known for its rapid response to remove microbes in
the bloodstream. However, relatively little is known about a functioning complement system …

While serum-circulating complement destroys invading pathogens, intracellularly active
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …

Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer
disease; however, their interrelatedness remains poorly understood. The complement …