Elusive roles for reactive astrocytes in neurodegenerative diseases
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …
response. They become reactive in response to virtually all pathological situations in the …
The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges
Inflammation is a fundamental response of the immune system whose successful
termination involves the elimination of the invading pathogens, the resolution of …
termination involves the elimination of the invading pathogens, the resolution of …
[HTML][HTML] STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3)
is activated constitutively in a wide array of human cancers. It is an appealing molecular …
is activated constitutively in a wide array of human cancers. It is an appealing molecular …
[HTML][HTML] IL-22+ CD4+ T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
Little is known about how the immune system impacts human colorectal cancer
invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient colorectal …
invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient colorectal …
STAT3 in the systemic inflammation of cancer cachexia
Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
Plasma cell responses are associated with anti-tumor immunity and favorable response to
immunotherapy. B cells can amplify anti-tumor immune responses through antibody …
immunotherapy. B cells can amplify anti-tumor immune responses through antibody …
The JAK/STAT pathway in skeletal muscle pathophysiology
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is a
key intracellular mediator of a variety of metabolically relevant hormones and cytokines …
key intracellular mediator of a variety of metabolically relevant hormones and cytokines …
The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway?
K Ceyzériat, L Abjean, MA Carrillo-de Sauvage… - Neuroscience, 2016 - Elsevier
Astrocytes play multiple important roles in brain physiology. In pathological conditions, they
become reactive, which is characterized by morphological changes and upregulation of …
become reactive, which is characterized by morphological changes and upregulation of …
Transcription factors: specific DNA binding and specific gene regulation
Specific recognition of cis-regulatory regions is essential for correct gene regulation in
response to developmental and environmental signals. Such DNA sequences are …
response to developmental and environmental signals. Such DNA sequences are …
PTP1B: a simple enzyme for a complex world
Our understanding of the fundamental regulatory roles that tyrosine phosphatases play
within cells has advanced significantly in the last two decades. Out-dated ideas that tyrosine …
within cells has advanced significantly in the last two decades. Out-dated ideas that tyrosine …