Zika virus: History, emergence, biology, and prospects for control
Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile,
Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to …
Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to …
Therapeutic potential of spirooxindoles as antiviral agents
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low
toxicity remain challenging, and obtaining such agents continues to be an active area of …
toxicity remain challenging, and obtaining such agents continues to be an active area of …
The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development
The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
Current trends and limitations in dengue antiviral research
Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
Defining Hsp70 subnetworks in dengue virus replication reveals key vulnerability in flavivirus infection
Viral protein homeostasis depends entirely on the machinery of the infected cell.
Accordingly, viruses can illuminate the interplay between cellular proteostasis components …
Accordingly, viruses can illuminate the interplay between cellular proteostasis components …
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction
Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …
Baicalin, a metabolite of baicalein with antiviral activity against dengue virus
Baicalin, a flavonoid derived from Scutellaria baicalensis, is the main metabolite of baicalein
released following administration in different animal models and human. We previously …
released following administration in different animal models and human. We previously …
The role of host cholesterol during flavivirus infection
In recent years the emergence and resurgence of arboviruses have generated a global
health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and …
health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and …
Molecular mechanisms of antiviral agents against dengue virus
Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …
The dengue virus NS5 protein as a target for drug discovery
The non-structural protein 5 (NS5) of flaviviruses is the most conserved amongst the viral
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …