[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery

EM Del Amo, AK Rimpelä, E Heikkinen, OK Kari… - Progress in retinal and …, 2017 - Elsevier
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

Hyaluronic acid in ocular drug delivery

X Zhang, D Wei, Y Xu, Q Zhu - Carbohydrate Polymers, 2021 - Elsevier
As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues,
hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry …

Design of experiments for microencapsulation applications: A review

F Paulo, L Santos - Materials Science and Engineering: C, 2017 - Elsevier
Microencapsulation techniques have been intensively explored by many research sectors
such as pharmaceutical and food industries. Microencapsulation allows to protect the active …

Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: state-of-the-art and challenges

F Ramazani, W Chen, CF Van Nostrum, G Storm… - International journal of …, 2016 - Elsevier
Abstract Poly (lactide-co-glycolide)(PLGA) microspheres are efficient delivery systems for
controlled release of low molecular weight drugs as well as therapeutic macromolecules …

Clinically established biodegradable long acting injectables: an industry perspective

CI Nkanga, A Fisch, M Rad-Malekshahi… - Advanced drug delivery …, 2020 - Elsevier
Long acting injectable formulations have been developed to sustain the action of drugs in
the body over desired periods of time. These delivery platforms have been utilized for both …

Current state and opportunities with long-acting injectables: industry perspectives from the innovation and quality consortium “long-acting injectables” working group

A Bauer, P Berben, SS Chakravarthi… - Pharmaceutical …, 2023 - Springer
Long-acting injectable (LAI) formulations can provide several advantages over the more
traditional oral formulation as drug product opportunities. LAI formulations can achieve …

[HTML][HTML] The effect of particle size on drug bioavailability in various parts of the body

ZH Mok - Pharmaceutical Science Advances, 2024 - Elsevier
Multiple mechanisms are involved in driving the efficacy of drug delivery. Drug particle size
is one of the challenges as particles need to be delivered from the external environment, into …

Advances in ocular drug delivery systems

JJ Kang-Mieler, KM Rudeen, W Liu, WF Mieler - Eye, 2020 - nature.com
Recent advances in pharmacological agents have led to successful treatment of a variety of
retinal diseases such as neovascular age-related macular degeneration (AMD), diabetic …

Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress

Y Shen, J Sun, X Sun - Journal of Nanobiotechnology, 2023 - Springer
Glaucoma is a leading cause of irreversible visual impairment and blindness, affecting over
76.0 million people worldwide in 2020, with a predicted increase to 111.8 million by 2040 …

Critical analysis of techniques and materials used in devices, syringes, and needles used for intravitreal injections

GB Melo, NFS da Cruz, GG Emerson… - Progress in Retinal and …, 2021 - Elsevier
Intravitreal injections have become the most commonly performed intraocular treatments
worldwide. Because intravitreal injections may induce severe adverse events, such as …