Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

One of the major challenges limiting the efficacy of anti–PD-1/PD-L1 therapy in
nonresponding patients is the failure of T cells to penetrate the tumor microenvironment. We …

During times of stress, autophagy is a cellular process that enables cells to reclaim
damaged components by a controlled recycling pathway. This mechanism for cellular …

Autophagy plays a vital role in sustaining cellular homeostasis and its alterations have been
implicated in the etiology of many diseases. Drugs development targeting autophagy began …

There is substantial interest in memory reconsolidation as a target for the treatment of
anxiety disorders, such as post-traumatic stress disorder. However, its applicability is …

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death-1/anti-
programmed cell death ligand-1 (anti-PD-1/PD-L1) therapy, have elicited impressive clinical …

High glucose-regulated protein 78 (GRP78) expression contributes to the acquisition of a
wide range of phenotypic cancer hallmarks and the pleiotropic oncogenic functions of …

Autophagy is a critical regulator of cellular homeostasis and metabolism. Interference with
this process is considered a new approach for the treatment of disease, in particular cancer …

An immunosuppressive tumor microenvironment promotes tumor growth and is one of the
main factors limiting the response to cancer immunotherapy. We have previously reported …