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The fundamental role of epigenetic events in cancer
Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …
DNA methyltransferases, DNA damage repair, and cancer
B **, KD Robertson - Epigenetic alterations in oncogenesis, 2012 - Springer
The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …
[HTML][HTML] The epigenomics of cancer
Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …
Epigenetics in cancer
M Esteller - New England Journal of Medicine, 2008 - Mass Medical Soc
Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
Gene silencing in cancer in association with promoter hypermethylation
This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …
Epigenetic determinants of cancer
Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …
Cancer epigenomics: DNA methylomes and histone-modification maps
M Esteller - Nature reviews genetics, 2007 - nature.com
An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
Genomic and epigenetic instability in colorectal cancer pathogenesis
WM Grady, JM Carethers - Gastroenterology, 2008 - Elsevier
Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
M Esteller - Oncogene, 2002 - nature.com
We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …
DNA methylation and gene silencing in cancer
SB Baylin - Nature clinical practice Oncology, 2005 - nature.com
Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …
mammalian development. However, promoter hypermethylation also plays a major role in …