Myocardial infarction (MI) is a major disease posing a significant threat to human health, as it
leads to necrosis of numerous cardiomyocytes (CMs), left ventricle dilation, and cardiac …

The development of biomaterials for cardiac tissue engineering (CTE) is challenging,
primarily owing to the requirement of achieving a surface with favourable characteristics that …

Background—Phase I clinical studies have demonstrated the feasibility of implanting
autologous skeletal myoblasts in postinfarction scars. However, they have failed to …

Over the past decade, tissue-engineering strategies, mainly involving injectable hydrogels
and epicardial biomaterial patches, have been pursued to treat myocardial infarction …

Myocardial infarction (MI) leads to massive cardiomyocyte death and deposition of collagen
fibers. This fibrous tissue disrupts electrical signaling in the myocardium, leading to cardiac …

Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Clinical percutaneous delivery of synthetically engineered hydrogels remains limited due to
challenges posed by crosslinking kinetics—too fast leads to delivery failure, too slow limits …

The myocardial tissue lacks significant intrinsic regenerative capability to replace the lost
cells. Therefore, the heart is a major target of research within the field of tissue engineering …

Alginate biomaterial is widely utilized for tissue engineering and regeneration due to its
biocompatibility, non-thrombogenic nature, mild and physical gelation process, and the …

In the multidisciplinary field of heart research it is of utmost importance to identify accurate
myocardium material properties for the description of phenomena such as mechano-electric …