Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: a narrative review

WJ Mei, M Mi, J Qian, N **ao, Y Yuan… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch
repair (dMMR) show molecular and clinicopathological characteristics that differ from those …

Racial disparities in colorectal cancer clinicopathological and molecular tumor characteristics: a systematic review

T Lawler, L Parlato, S Warren Andersen - Cancer Causes & Control, 2024 - Springer
Abstract Purpose African Americans have the highest colorectal cancer (CRC) mortality of all
racial groups in the USA, which may relate to differences in healthcare access or advanced …

Genomic landscape of colorectal carcinoma in sub-Saharan Africa

AP Aldera, K Pillay, B Robertson, A Boutall… - Journal of Clinical …, 2023 - jcp.bmj.com
Our understanding of the molecular classification of colorectal carcinoma (CRC) has
evolved significantly over the past two decades. Tumours can be broadly categorised as …

[HTML][HTML] MLH1 Methylation Status and Microsatellite Instability in Patients with Colorectal Cancer

MA Rico-Méndez, MA Trujillo-Rojas… - Genes, 2025 - mdpi.com
Background/Objectives: The purpose of the current study was to compare the methylation of
five regions of the CpG island of MLH1 with the presence of microsatellite instability (MSI) in …

Immunohistochemical determination of mismatch repair gene product in colorectal carcinomas in a young indigenous African cohort

R Holla, A Vorster, M Locketz, M De Haas… - South African Journal of …, 2022 - ajol.info
Background: Colorectal cancer (CRC) in the indigenous African population of South Africa is
uncommon (age standardised incidence rates of 11.29 for males and 7.27/100 000 for …

Investigating somatic variants and pathways in mismatch repair-deficient (dMMR) colorectal carcinoma in South Africa

AP Aldera, J van der Westhuizen, WJ Tsai… - Journal of Clinical …, 2024 - jcp.bmj.com
Aims Colorectal carcinoma (CRC) is a common cause of morbidity and mortality worldwide,
and an emerging public health problem in sub-Saharan Africa. Several authors have …

Racial differences in the phenotype of colorectal cancer: A prospective comparison between Nigeria and South Africa

OI Alatise, GC Knapp, B Bebington… - World journal of …, 2022 - Wiley Online Library
Introduction There are significant differences in the phenotype of CRC by race in the US A
similar CRC phenotype‐race relationship also appears to exist in South Africa (SA) …

Deficient Mismatch Repair and BRAF Mutations in Metastatic Colorectal Cancer in the South Island of New Zealand

J Yap, S Pattison - Asia‐Pacific Journal of Clinical Oncology, 2025 - Wiley Online Library
ABSTRACT Aim Manatū Hauora, the Ministry of Health of New Zealand (NZ), published
minimum standards for molecular testing of colorectal cancers (CRCs) in June 2018. These …

Evaluating utility and feasibility of mismatch repair testing of colorectal cancer patients in a low-middle-income country

I Elsayed, R Geraghty, SO Mekki, AA Mohamedani… - Scientific Reports, 2022 - nature.com
Molecular pathology services for colorectal cancer (CRC) in Sudan represent a significant
unmet clinical need. In a retrospective cohort study involving 50 patients diagnosed with …

Left-sided colorectal cancer distinct in indigenous African patients compared to other ethnic groups in South Africa

M McCabe, C Penny, P Magangane, S Mirza, Y Perner - BMC cancer, 2022 - Springer
Introduction A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in
South Africa are young (< 50 years), with no unique histopathological or molecular …