Structural and Mechanistic Insights into the Main Protease (Mpro) Dimer Interface Destabilization Inhibitor: Unveiling New Therapeutic Avenues against SARS-CoV-2

A Singh, K Jangid, S Nehul, P Dhaka, R Rani… - Biochemistry, 2024 - ACS Publications
SARS-CoV-2 variant recurrence has emphasized the imperative prerequisite for effective
antivirals. The main protease (Mpro) of SARS-CoV-2 is crucial for viral replication, making it …

[PDF][PDF] Structural Virology: The Key Determinants in Development of Antiviral Therapeutics

T Handa, A Saha, A Narayanan, E Ronzier, P Kumar… - 2025 - preprints.org
Structural virology has emerged as the foundation for the development of effective antiviral
therapeutics. It is pivotal in providing crucial insights into the three-dimensional frame of …