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Preclinical models of cardiac disease: a comprehensive overview for clinical scientists
For recent decades, cardiac diseases have been the leading cause of death and morbidity
worldwide. Despite significant achievements in their management, profound understanding …
worldwide. Despite significant achievements in their management, profound understanding …
[HTML][HTML] Ion channels in epithelial dynamics and morphogenesis
Mechanosensitive ion channels mediate the neuronal sensation of mechanical signals such
as sound, touch, and pain. Recent studies point to a function of these channel proteins in …
as sound, touch, and pain. Recent studies point to a function of these channel proteins in …
cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities
Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of
hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM …
hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM …
The interplay between cell-cell and cell-matrix forces regulates cell migration dynamics
Cells in vivo encounter and exert forces as they interact with the extracellular matrix (ECM)
and neighboring cells during migration. These mechanical forces play crucial roles in …
and neighboring cells during migration. These mechanical forces play crucial roles in …
Micropattern platform promotes extracellular matrix remodeling by human PSC‐derived cardiac fibroblasts and enhances contractility of co‐cultured cardiomyocytes
In native heart tissue, cardiac fibroblasts provide the structural framework of extracellular
matrix (ECM) while also influencing the electrical and mechanical properties of …
matrix (ECM) while also influencing the electrical and mechanical properties of …
Fabrication of Micropatterns of Aligned Collagen Fibrils
Many tissues in vivo contain aligned structures such as filaments, fibrils, and fibers, which
expose cells to anisotropic structural and topographical cues that range from the nanometer …
expose cells to anisotropic structural and topographical cues that range from the nanometer …
Cardiac tissue engineering: Multiple approaches and potential applications
The overall increase in cardiovascular diseases and, specifically, the ever-rising exposure to
cardiotoxic compounds has greatly increased in vivo animal testing; however, mainly due to …
cardiotoxic compounds has greatly increased in vivo animal testing; however, mainly due to …
Evaluation of an Inverse Method for Quantifying Spatially Variable Mechanics
Soft biological tissues often function as highly deformable membranes in vivo and exhibit
impressive mechanical behavior effectively characterized by planar biaxial testing. The …
impressive mechanical behavior effectively characterized by planar biaxial testing. The …
Influence of remodeled ECM and co-culture with iPSC-derived cardiac fibroblasts on the mechanical function of micropatterned iPSC-derived cardiomyocytes
Introduction In native heart tissue, functions of cardiac fibroblasts (CFs) include synthesis,
remodeling, and degradation of the extracellular matrix (ECM) as well as secreting factors …
remodeling, and degradation of the extracellular matrix (ECM) as well as secreting factors …
Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts
Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) have emerged as an
exciting new tool for cardiac research and can serve as a preclinical platform for drug …
exciting new tool for cardiac research and can serve as a preclinical platform for drug …