State of the evidence

KD Allen, YM Golightly - Current opinion in rheumatology, 2015 - journals.lww.com
Osteoarthritis is a complex, multifactorial disease, and there is still much to learn regarding
mechanisms underlying incidence and progression. However, there are several known …

osteophytes

SHJ Wong, KY Chiu, CH Yan - Journal of orthopaedic …, 2016 - journals.sagepub.com
An osteophyte is a fibrocartilage-capped bony outgrowth that is one of the features of
osteoarthritis. This study reviewed the types, risk factors, pathophysiology, clinical …

Causal factors for knee, hip, and hand osteoarthritis: a Mendelian randomization study in the UK Biobank

T Funck‐Brentano, M Nethander… - Arthritis & …, 2019 - Wiley Online Library
Objective There is no curative treatment for osteoarthritis (OA), which is the most common
form of arthritis. This study was undertaken to identify causal risk factors of knee, hip, and …

Causal relationship between osteoporosis and osteoarthritis: A two-sample Mendelian randomized study

L Lin, P Luo, M Yang, J Wang, W Hou… - Frontiers in …, 2022 - frontiersin.org
Introduction At present, clinical studies have confirmed that osteoporosis (OP) has an
inverse relationship with osteoarthritis (OA), but it has not been proven from the point of view …

Machine learning outperforms clinical experts in classification of hip fractures

EA Murphy, B Ehrhardt, CL Gregson, OA von Arx… - Scientific reports, 2022 - nature.com
Hip fractures are a major cause of morbidity and mortality in the elderly, and incur high
health and social care costs. Given projected population ageing, the number of incident hip …

Hip pain and mobility deficits—hip osteoarthritis: revision 2017: clinical practice guidelines linked to the international classification of functioning, disability and health …

MT Cibulka, NJ Bloom, KR Enseki… - Journal of Orthopaedic & …, 2017 - jospt.org
The Orthopaedic Section of the American Physical Therapy Association (APTA) has an
ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy …

Osteoarthritis and bone mineral density: are strong bones bad for joints?

SA Hardcastle, P Dieppe, CL Gregson… - BoneKEy …, 2015 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is a common and disabling joint disorder affecting millions of people
worldwide. In OA, pathological changes are seen in all of the joint tissues including bone …

Wnt16 signaling in bone homeostasis and osteoarthristis

X Ye, X Liu - Frontiers in Endocrinology, 2022 - frontiersin.org
Wnts are secreted cysteine-rich glycoproteins involved in joint development and skeletal
homeostasis and have been implicated in the occurrence of osteoarthritis. Over the past …

A novel semi-automated classifier of hip osteoarthritis on DXA images shows expected relationships with clinical outcomes in UK Biobank

BG Faber, R Ebsim, FR Saunders, M Frysz… - …, 2022 - academic.oup.com
Objective Conventional scoring methods for radiographic hip OA (rHOA) are subjective and
show inconsistent relationships with clinical outcomes. To provide a more objective rHOA …

Osteophytes, enthesophytes, and high bone mass: a bone‐forming triad with potential relevance in osteoarthritis

SA Hardcastle, P Dieppe, CL Gregson… - Arthritis & …, 2014 - Wiley Online Library
Objective Previous studies of skeletal remains have suggested that both enthesophytes and
osteophytes are manifestations of an underlying bone‐forming tendency. A greater …