The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Importance Glaucoma is the most common cause of irreversible blindness worldwide. Many
patients with glaucoma are asymptomatic early in the disease course. Primary care …

Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

Retinal gene therapy has had unprecedented success in generating treatments that can halt
vision loss. However, immunogenic response and long-term toxicity with the use of viral …

Glaucoma is the result of the gradual death of retinal ganglion cells (RGCs) whose axons
form the optic nerve. Elevated intraocular pressure (IOP) is a major risk factor that …

The field of gene therapy has made significant strides over the last several decades toward
the treatment of previously untreatable genetic disease. Gene therapy techniques have …

Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

CRISPR/Cas9-mediated genome editing is a powerful technology that has been used for the
genetic modification of a number of crop species. In order to evaluate the efficacy of …