Insights into Alzheimer's disease from single-cell genomic approaches
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …
Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
Deep learning-based predictive identification of neural stem cell differentiation
The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …
devising potential cell-based therapeutic strategies for central nervous system (CNS) …
Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …
the mechanisms of which remain largely elusive. Recently, integration of technological …
Amplification of human interneuron progenitors promotes brain tumors and neurological defects
Evolutionary development of the human brain is characterized by the expansion of various
brain regions. Here, we show that developmental processes specific to humans are …
brain regions. Here, we show that developmental processes specific to humans are …
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The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …
types, a diversity that emerges during early brain development. To reveal the precise …
Map** human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?
The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …
or neurological diseases represents a particularly attractive alternative to conventional …
Tropism of SARS-CoV-2 for human cortical astrocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety
of cell types impacting the function of vital organ systems, with particularly severe impact on …
of cell types impacting the function of vital organ systems, with particularly severe impact on …
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function
Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …
rather a distinct and heterogeneous population of glia with various functions in the …