Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …

Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral
heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection …

The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

The human brain undergoes rapid development at mid-gestation from a pool of neural stem
and progenitor cells (NSPCs) that give rise to the neurons, oligodendrocytes, and astrocytes …

The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …

The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …

In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell
populations and their progeny, oligodendrocytes, emerge from three distinct regions in a …

Evolutionary development of the human brain is characterized by the expansion of various
brain regions. Here, we show that developmental processes specific to humans are …