Recent developments on polysaccharide-based chiral stationary phases for liquid-phase separation of enantiomers

B Chankvetadze - Journal of chromatography A, 2012 - Elsevier
This paper summarizes recent developments in the synthesis, application and mechanistic
studies on polysaccharide-based chiral stationary phases (CSPs) for liquid phase …

Membranes and membrane processes for chiral resolution

R **e, LY Chu, JG Deng - Chemical Society Reviews, 2008 - pubs.rsc.org
This critical review is devoted to an active field of research on chiral separation, membrane-
based enantioseparation technique, which has potential for large-scale production of single …

Enantioseparation and molecular docking study of selected chiral pharmaceuticals on a commercialized phenylcarbamate-β-cyclodextrin column using polar organic …

M Dobó, M Ádám, B Fiser, LA Papp, G Dombi… - Scientific Reports, 2023 - nature.com
The chiral separation capability of Chiral-CD-Ph column, containing phenylcarbamate-β-
cyclodextrin as the chiral selector in polar organic mode was investigated. A total of twenty …

General screening and optimization strategy for fast chiral separations in modern supercritical fluid chromatography

L Nováková, M Douša - Analytica Chimica Acta, 2017 - Elsevier
High throughput general chiral screening method using supercritical fluid chromatography
was developed. This method takes an advantage of very fast gradient screening (3 min+ 1 …

Determination of chiral impurity of naproxen in different pharmaceutical formulations using polysaccharide-based stationary phases in reversed-phased mode

LA Papp, S Krizbai, M Dobó, G Hancu, ZI Szabó… - Molecules, 2022 - mdpi.com
A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography
(HPLC) method was developed for the enantiopurity control analysis of naproxen, a …

Cellulose tris (3, 5-dichlorophenylcarbamate) immobilised on silica: a novel chiral stationary phase for resolution of enantiomers

T Zhang, D Nguyen, P Franco, Y Isobe… - … of Pharmaceutical and …, 2008 - Elsevier
CHIRALPAK IC is a new chiral stationary phase (CSP) made by immobilising cellulose tris
(3, 5-dichlorophenylcarbamate) on silica gel. The chiral selector is distinct from any other …

Macrocyclic glycopeptide chiral selectors bonded to core-shell particles enables enantiopurity analysis of the entire verubecestat synthetic route

CL Barhate, DA Lopez, AA Makarov, X Bu… - … of Chromatography A, 2018 - Elsevier
Verubecestat is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1)
being evaluated in clinical trials for the treatment of Alzheimer's disease. Synthetic route …

High-performance liquid chromatographic enantioseparations on monolithic silica columns containing a covalently attached 3, 5-dimethylphenylcarbamate derivative …

B Chankvetadze, T Ikai, C Yamamoto… - … of Chromatography A, 2004 - Elsevier
Covalent immobilization of 3, 5-dimethylphenylcarbamate derivative of cellulose was
performed in situ onto native silica monoliths cladded in a 50mm× 4.6 mm polyether ether …

Cellulose 3, 5-dimethylphenylcarbamate immobilized on silica: A new chiral stationary phase for the analysis of enantiomers

T Zhang, D Nguyen, P Franco, T Murakami… - Analytica chimica …, 2006 - Elsevier
Recently, we have reported the solvent versatility and enantiomeric resolution performance
of an immobilized amylose derivative-based chiral stationary phase (CSP), CHIRALPAK® …

Polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography: an overview

B Chankvetadze - Chiral separations: methods and protocols, 2019 - Springer
This chapter summarizes the application of polysaccharide-based chiral stationary phases
(CSPs) for separation of enantiomers in high-performance liquid chromatography (HPLC) …