Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-
HSCs) sense demand from daily and stress-mediated cues and then transition into …

Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

Abstract N 6-methyladenosine (m6A), the most prevalent mRNA modification, has an
important function in diverse biological processes. However, the involvement of m6A in …

The mechanisms underlying metabolic adaptation of pancreatic ductal adenocarcinoma
(PDA) cells to pharmacologic inhibition of RAS–MAPK signaling are largely unknown. Using …