In the last 4 years, several evidence-based, national, and international guidelines on the
management of arterial hypertension have been published, mostly with concordant …

Several articles have dealt with the importance and mechanisms of the sympathetic nervous
system alterations in experimental animal models of hypertension. This review addresses …

Background Previous randomised renal denervation studies did not show consistent efficacy
in reducing blood pressure. The objective of our study was to evaluate the effect of renal …

Aims Several studies and registries have demonstrated sustained reductions in blood
pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in …

The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

Abstract Aims The SYMPLICITY HTN-3 randomized, blinded, sham-controlled trial confirmed
the safety of renal denervation (RDN), but did not meet its primary efficacy endpoint. Prior …

Background Renal denervation (RDN) with radiofrequency ablation substantially reduces
blood pressure in patients with treatment-resistant hypertension. We assessed the long-term …

BACKGROUND: Activation of renal sympathetic nerves is key to pathogenesis of essential
hypertension. We aimed to assess effectiveness and safety of catheter-based renal …

Background Renal sympathetic hyperactivity is associated with hypertension and its
progression, chronic kidney disease, and heart failure. We did a proof-of-principle trial of …

Hypertension is the most common modifiable risk factor for cardiovascular disease and
death, and lowering blood pressure with antihypertensive drugs reduces target organ …