Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

During evolution, individuals whose brains and bodies functioned well in a fasted state were
successful in acquiring food, enabling their survival and reproduction. With fasting and …

Humans in modern societies typically consume food at least three times daily, while
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …

Objective: A randomized, placebo-controlled, double-blind, multicenter 52-week phase 2
trial of resveratrol in individuals with mild to moderate Alzheimer disease (AD) examined its …

The accumulation of misfolded proteins in the human brain is one of the critical features of
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …

The amyloid hypothesis suggests that the progressive accumulation and deposition of
central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's …

Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are
associated with healthy aging in humans, and dietary protein restriction extends the lifespan …

Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …