Effects of PACAP on Schwann cells: focus on nerve injury

G Maugeri, AG D'Amico, G Musumeci… - International Journal of …, 2020 - mdpi.com
Schwann cells, the most abundant glial cells of the peripheral nervous system, represent the
key players able to supply extracellular microenvironment for axonal regrowth and …

Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity

C Lefebvre-Omar, E Liu, C Dalle, BL d'Incamps… - Cellular and Molecular …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …

[HTML][HTML] Multimodal role of PACAP in glioblastoma

AG D'Amico, G Maugeri, L Vanella, V Pittalà, D Reglodi… - Brain Sciences, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the deadliest form of brain tumors. To date, the GBM
therapeutical approach consists of surgery, radiation-therapy and chemotherapy combined …

[HTML][HTML] Effect of PACAP on hypoxia-induced angiogenesis and epithelial–mesenchymal transition in glioblastoma

G Maugeri, AG D'Amico, S Saccone, C Federico… - Biomedicines, 2021 - mdpi.com
Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts different effects in various
human cancer. In glioblastoma (GBM), PACAP has been shown to interfere with the hypoxic …

[HTML][HTML] VEGF expression disparities in brainstem motor neurons of the SOD1G93A ALS model: Correlations with neuronal vulnerability

S Silva-Hucha, MEF de Sevilla, KM Humphreys… - …, 2024 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by
severe muscle weakness mainly due to degeneration and death of motor neurons. A …

PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer's disease

Q Wang, Y Wang, S Li, J Shi - Alzheimer's Research & Therapy, 2023 - Springer
Background Autophagy is vital in the pathogenesis of neurodegeneration. Thus far, no
studies have specifically investigated the relationship between pituitary adenylate cyclase …

Distribution of PACAP and PAC1 Receptor in the Human Eye

E Patko, E Szabo, D Toth, T Tornoczky… - Journal of Molecular …, 2022 - Springer
Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide with
widespread distribution and diverse biological functions. Several studies show that PACAP …

Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) counteracts UV-B radiation-induced ROS Formation in corneal epithelium

G Maugeri, AG D'Amico, S Giunta, C Giallongo… - Antioxidants, 2022 - mdpi.com
The corneal epithelium, the outermost layer of the cornea, acts as a dynamic barrier
preventing access to harmful agents into the intraocular space. It is subjected daily to …

Perspective role of Substance P in Amyotrophic Lateral Sclerosis: from neuronal vulnerability to neuroprotection

P Tirassa, R Pamela, F Elena, M Marenco… - Neuroscience & …, 2024 - Elsevier
Abstract The neuropeptide Substance P (SP) and its preferred Neurokinin1 Receptor
(NK1R) are known to participate in the physiopathology of neurodegenerative diseases and …

Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report

C Lombardo, G Maugeri, AG D'Amico… - European Journal …, 2024 - pmc.ncbi.nlm.nih.gov
Pleural mesothelioma is a devastating malignancy primarily associated with asbestos
exposure. However, emerging evidence suggests that exposure to fluoro-edenite fibers, a …