SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside
SLC39A8 is an evolutionarily highly conserved gene that encodes the ZIP8 metal cation
transporter in all vertebrates. SLC39A8 is ubiquitously expressed, including pluripotent …
transporter in all vertebrates. SLC39A8 is ubiquitously expressed, including pluripotent …
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …
Although genome-wide association studies have identified PAU risk genes, the genetic …
Alcohol use and dementia: new research directions
Future research would benefit from greater implementation of analytical and design-based
approaches to robustly model the alcohol use-dementia relationship in the general …
approaches to robustly model the alcohol use-dementia relationship in the general …
A population-based phenome-wide association study of cardiac and aortic structure and function
Differences in cardiac and aortic structure and function are associated with cardiovascular
diseases and a wide range of other types of disease. Here we analyzed cardiovascular …
diseases and a wide range of other types of disease. Here we analyzed cardiovascular …
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
S Sanchez-Roige, MV Jennings, HHA Thorpe… - Translational …, 2023 - nature.com
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …
act prematurely and is associated with multiple forms of psychopathology, including …
The dopamine transporter gene SLC6A3: multidisease risks
MEA Reith, S Kortagere, CE Wiers, H Sun… - Molecular …, 2022 - nature.com
The human dopamine transporter gene SLC6A3 has been consistently implicated in several
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …
Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes
Genome-wide association studies (GWAS) have discovered numerous genetic variants
associated with human behavioural traits. However, behavioural traits are subject to …
associated with human behavioural traits. However, behavioural traits are subject to …
Item-level genome-wide association study of the alcohol use disorders identification test in three population-based cohorts
Objective: Genome-wide association studies (GWASs) of the Alcohol Use Disorders
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …
Genetic mechanisms of COVID-19 and its association with smoking and alcohol consumption
We aimed to investigate the genetic mechanisms associated with coronavirus disease of
2019 (COVID-19) outcomes in the host and to evaluate the possible associations between …
2019 (COVID-19) outcomes in the host and to evaluate the possible associations between …
Recent efforts to dissect the genetic basis of alcohol use and abuse
Alcohol use disorder (AUD) is defined by several symptom criteria, which can be dissected
further at the genetic level. Over the past several years, our understanding of the genetic …
further at the genetic level. Over the past several years, our understanding of the genetic …