The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The sustenance of life depends on the high degree of organization that prevails through
different levels of living organisms, from subcellular structures such as biomolecular …

Aurora B kinase has a critical role in regulating attachments between kinetochores and
spindle microtubules during mitosis. Early in mitosis, kinase activity at kinetochores is high to …

Aurora B kinase is essential for faithful chromosome segregation during mitosis. During (pro)
metaphase, Aurora B is concentrated at the inner centromere by the kinases Haspin and …

Aurora B kinase plays an essential role in chromosome bi-orientation, which is a
prerequisite for equal segregation of chromosomes during mitosis. However, it remains …

Metaphase spindles exert pole-directed forces on still-connected sister kinetochores. The
spindle must counter these forces with extensive forces to prevent spindle collapse. In small …

During cell division, kinetochores link chromosomes to spindle microtubules. The Ndc80
complex, a crucial microtubule binder, populates each kinetochore with dozens of copies …

STUDY QUESTION Is the combined use of fluorescence lifetime imaging microscopy (FLIM)-
based metabolic imaging and second harmonic generation (SHG) spindle imaging a …

The fidelity of chromosome segregation during mitosis is intimately linked to the function of
kinetochores, which are large protein complexes assembled at sites of centromeric …

Successful mitotic cell division is critically dependent on the formation of correct attachments
between chromosomes and spindle microtubules. Microtubule attachments are mediated by …