Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of
people after COVID-19 and represent a major component of the post-acute COVID-19 …

Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …

Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …

Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being re-discovered as regulators of …