The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

In this Beyond the Cell review, we focus on five stages of the journey of insulin through the
body and the captivating cell biology that underlies its connections with each organ. We …

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

Organelles are functional areas where eukaryotic cells perform processes necessary for life.
Each organelle performs specific functions; however, highly coordinated crosstalk occurs …

The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its
biophysical properties and relevance to cell death, bioenergetics and signalling have been …

In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have
been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …