Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
Long-acting parenteral drug delivery systems for the treatment of chronic diseases
The management of chronic conditions often requires patients to take daily medication for an
extended duration. However, the need for daily dosing can lead to nonadherence to the …
extended duration. However, the need for daily dosing can lead to nonadherence to the …
Challenges and opportunities in metastatic breast cancer treatments: Nano-drug combinations delivered preferentially to metastatic cells may enhance therapeutic …
Despite advances in breast cancer treatments and related 5-year survival outcomes,
metastatic breast cancer cures remain elusive. The current standard of care includes a …
metastatic breast cancer cures remain elusive. The current standard of care includes a …
Enhanced intradermal delivery of nanosuspensions of antifilariasis drugs using dissolving microneedles: a proof of concept study
Conventional oral administration of antifilariasis drugs results in nonspecific targeting of the
drugs and the intradermal delivery of nanoparticles with sizes of< 100 nm could be used to …
drugs and the intradermal delivery of nanoparticles with sizes of< 100 nm could be used to …
[HTML][HTML] Battle of the milky way: Lymphatic targeted drug delivery for pathogen eradication
Many viruses, bacteria, and parasites rely on the lymphatic system for survival, replication,
and dissemination. While conventional anti-infectives can combat infection-causing agents …
and dissemination. While conventional anti-infectives can combat infection-causing agents …
An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression
Treatment of chronic hepatitis B virus (HBV) requires lifelong daily therapy. However,
suboptimal adherence to the existing daily therapy has led to the need for ultralong-acting …
suboptimal adherence to the existing daily therapy has led to the need for ultralong-acting …
Nanocrystals for controlled delivery: state of the art and approved drug products
Introduction Controlled/extended-release formulations offer numerous benefits over
conventional especially reduced side effects, improved therapeutic outcomes, and high …
conventional especially reduced side effects, improved therapeutic outcomes, and high …
Chronic hepatitis B infection: New approaches towards cure
Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and
hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is …
hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is …
Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach
The combined antiretroviral therapy (cART) can efficiently suppress HIV replication, but the
cessation of cART usually results in viral rebound, mostly due to the presence of viral …
cessation of cART usually results in viral rebound, mostly due to the presence of viral …
Physiologically based pharmacokinetic model validated to enable predictions of multiple drugs in a long-acting drug-combination nano-particles (DCNP): confirmation …
S Perazzolo, DD Shen, AM Scott, RJY Ho - Journal of Pharmaceutical …, 2024 - Elsevier
Abstract Drug-Combination Nanoparticles (DcNP) are a novel drug delivery system
designed for synchronized delivery of multiple drugs in a single, long-acting, and targeted …
designed for synchronized delivery of multiple drugs in a single, long-acting, and targeted …