DNA methylation testing for endometrial cancer detection in urine, cervicovaginal self‐samples and cervical scrapes

BMM Wever, R van den Helder… - … journal of cancer, 2023 - Wiley Online Library
Endometrial cancer incidence is rising and current diagnostics often require invasive biopsy
procedures. DNA methylation marker analysis of minimally‐and non‐invasive sample types …

Performance of the WID-qEC test versus sonography to detect uterine cancers in women with abnormal uterine bleeding (EPI-SURE): a prospective, consecutive …

I Evans, D Reisel, A Jones, A Bajrami, S Nijjar… - The Lancet …, 2023 - thelancet.com
Background To detect uterine cancer, simpler and more specific index tests are needed to
triage women with abnormal uterine bleeding to a reference histology test. We aimed to …

High performance of the DNA methylation‐based WID‐qEC test for detecting uterine cancers independent of sampling modalities

O Illah, M Scott, E Redl, JE Barrett… - … Journal of Cancer, 2024 - Wiley Online Library
Endometrial cancer (EC) is the most prevalent gynaecological cancer in high‐income
countries and its incidence is continuing to rise sharply. Simple and objective tools to …

The WID‐EC test for the detection and risk prediction of endometrial cancer

JE Barrett, A Jones, I Evans, C Herzog… - … Journal of Cancer, 2023 - Wiley Online Library
The incidence of endometrial cancer is rising. Measures to identify women at risk and to
detect endometrial cancer earlier are required to reduce the morbidity triggered by the …

Detection of endometrial cancer using tampon-based collection and methylated DNA markers

JN Bakkum-Gamez, ME Sherman, SW Slettedahl… - Gynecologic …, 2023 - Elsevier
Objective Alterations in DNA methylation are early events in endometrial cancer (EC)
development and may have utility in EC detection via tampon-collected vaginal fluid …

[HTML][HTML] Advancements in Minimally Invasive Techniques and Biomarkers for the Early Detection of Endometrial Cancer: A Comprehensive Review of Novel …

A Asaturova, A Zaretsky, A Rogozhina… - Journal of Clinical …, 2024 - mdpi.com
This review evaluates the advances in the early detection and diagnosis of endometrial
cancer (EC), emphasizing the growing importance of minimally invasive techniques and …

The accuracy of DNA methylation detection in endometrial cancer screening: A systematic review and meta‐analysis

R Ran, M Wang, JW Miao - International Journal of Gynecology …, 2024 - Wiley Online Library
Objective DNA methylation is the hallmark of early endometrial cancer and can be detected
through non‐invasive methods. The present study systematically reviewed the efficacy of …

Methylated DNA markers for sporadic colorectal and endometrial cancer are strongly associated with lynch syndrome cancers

RM Bramblet, JN Bakkum-Gamez… - Cancer Prevention …, 2023 - aacrjournals.org
Lynch syndrome (LS) markedly increases risks of colorectal and endometrial cancers. Early
detection biomarkers for LS cancers could reduce the needs for invasive screening and …

Performance of the WID‐qEC test to detect uterine cancers in black women with abnormal uterine bleeding: A prospective observational cohort study in Ghana

S Ken‐Amoah, E Redl, BKS Domson… - … Journal of Cancer, 2025 - Wiley Online Library
The burden of uterine cancer is growing and, in the US and UK, mortality rates are poorest
among black women. Early detection of these cancers is critical and poor performance of …

Epigenetics and methylation risk scores

KC Barnes - Implementation of Personalized Precision Medicine, 2025 - Elsevier
Epigenetics alters the physical structure of DNA and affects how DNA sequences are
transcribed in gene expression. Unlike gene expression, also known as transcriptomics …