A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …

Chronic bacterial infections are caused by pathogens that persist within their hosts and
avoid clearance by the immune system. Treatment and/or detection of such pathogens is …

Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible
humans. Here, we infected Diversity Outbred (DO) mice with∼ 100 bacilli by aerosol to …

Many studies of Mycobacterium tuberculosis infection and immunity have used mouse
models. However, outcomes of vaccination and challenge with M. tuberculosis in inbred …

Because most humans resist Mycobacterium tuberculosis infection, there is a paucity of lung
samples to study. To address this gap, we infected Diversity Outbred mice with M …

Anthracyclines cause progressive cardiotoxicity whose ultimate severity is individual to the
patient. Genetic determinants contributing to this variation are difficult to study using current …

More humans have died of tuberculosis (TB) than any other infectious disease and millions
still die each year. Experts advocate for blood-based, serum protein biomarkers to help …

Background Machine learning sustains successful application to many diagnostic and
prognostic problems in computational histopathology. Yet, few efforts have been made to …

Tuberculosis (TB), primarily affecting the lungs, is caused by the bacterium Mycobacterium
tuberculosis and poses a significant health risk. Detecting acid-fast bacilli (AFB) in stained …

Mycobacterium tuberculosis infects two billion people across the globe, and results in 8–9
million new tuberculosis (TB) cases and 1–1.5 million deaths each year. Most patients have …