A reference cell tree will serve science better than a reference cell atlas

S Domcke, J Shendure - Cell, 2023 - cell.com
Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …

Inference and applications of ancestral recombination graphs

R Nielsen, AH Vaughn, Y Deng - Nature Reviews Genetics, 2025 - nature.com
Ancestral recombination graphs (ARGs) summarize the complex genealogical relationships
between individuals represented in a sample of DNA sequences. Their use is currently …

Learning the protein language: Evolution, structure, and function

T Bepler, B Berger - Cell systems, 2021 - cell.com
Language models have recently emerged as a powerful machine-learning approach for
distilling information from massive protein sequence databases. From readily available …

[BUCH][B] Handbook of approximate Bayesian computation

SA Sisson, Y Fan, M Beaumont - 2018 - books.google.com
As the world becomes increasingly complex, so do the statistical models required to analyse
the challenging problems ahead. For the very first time in a single volume, the Handbook of …

Delimiting species using single-locus data and the Generalized Mixed Yule Coalescent approach: a revised method and evaluation on simulated data sets

T Fujisawa, TG Barraclough - Systematic biology, 2013 - academic.oup.com
DNA barcoding-type studies assemble single-locus data from large samples of individuals
and species, and have provided new kinds of data for evolutionary surveys of diversity. An …

Genetics and the conservation of natural populations: allozymes to genomes

FW Allendorf - 2017 - Wiley Online Library
I consider how the study of genetic variation has influenced efforts to conserve natural
populations over the last 50 years. Studies with allozymes in the 1970s provided the first …

DnaSP v5: a software for comprehensive analysis of DNA polymorphism data

P Librado, J Rozas - Bioinformatics, 2009 - academic.oup.com
Motivation: DnaSP is a software package for a comprehensive analysis of DNA
polymorphism data. Version 5 implements a number of new features and analytical methods …

[HTML][HTML] Implementing and testing the multispecies coalescent model: a valuable paradigm for phylogenomics

SV Edwards, Z **, A Janke, BC Faircloth… - Molecular phylogenetics …, 2016 - Elsevier
In recent articles published in Molecular Phylogenetics and Evolution, Mark Springer and
John Gatesy (S&G) present numerous criticisms of recent implementations and testing of the …

Cancer evolution: mathematical models and computational inference

N Beerenwinkel, RF Schwarz, M Gerstung… - Systematic …, 2015 - academic.oup.com
Cancer is a somatic evolutionary process characterized by the accumulation of mutations,
which contribute to tumor growth, clinical progression, immune escape, and drug resistance …

DnaSP, DNA polymorphism analyses by the coalescent and other methods

J Rozas, JC Sánchez-DelBarrio, X Messeguer… - …, 2003 - academic.oup.com
DnaSP is a software package for the analysis of DNA polymorphism data. Present version
introduces several new modules and features which, among other options allow:(1) …