Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes

D Li, X Liu, T Liu, H Liu, L Tong, S Jia, YF Wang - Glia, 2020 - Wiley Online Library
Glial fibrillary acidic protein (GFAP), a type III intermediate filament, is a marker of mature
astrocytes. The expression of GFAP gene is regulated by many transcription factors (TFs) …

Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions

H Çelik, FM Kandemir, C Caglayan, S Özdemir… - Molecular biology …, 2020 - Springer
The purpose of the current study was to examine the neuroprotective effect of rutin against
colistin-induced neurotoxicity in rats. Thirty-five male Sprague Dawley rats were randomly …

Concentrically integrative bioassembly of a three-dimensional black phosphorus nanoscaffold for restoring neurogenesis, angiogenesis, and immune homeostasis

Y Qian, WE Yuan, Y Cheng, Y Yang, X Qu, C Fan - Nano Letters, 2019 - ACS Publications
Black phosphorus is well known for its excellent electromechanical properties. Although it
has previously been used for therapeutic drug delivery in cancer, it has never been applied …

Role of FABP7 in tumor cell signaling

Y Kagawa, BA Umaru, I Ariful, SK Shil… - Advances in biological …, 2019 - Elsevier
Lipids are major molecules for the function of organisms and are involved in the
pathophysiology of various diseases. Fatty acids (FAs) signaling and their metabolism are …

Intranasal insulin improves mitochondrial function and attenuates motor deficits in a rat 6‐OHDA model of Parkinson's disease

F Iravanpour, L Dargahi, M Rezaei… - CNS Neuroscience …, 2021 - Wiley Online Library
Aims Experimental and clinical evidences demonstrate that common dysregulated pathways
are involved in Parkinson's disease (PD) and type 2 diabetes. Recently, insulin treatment …

The FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial‐to‐mesenchymal transition and lipid‐derived energy production in prostate …

RZ Liu, WS Choi, S Jain, D Dinakaran, X Xu… - Molecular …, 2020 - Wiley Online Library
Early stage localized prostate cancer (PCa) has an excellent prognosis; however, patient
survival drops dramatically when PCa metastasizes. The molecular mechanisms underlying …

Omega-3 polyunsaturated fatty acid eicosapentaenoic acid or docosahexaenoic acid improved ageing-associated cognitive decline by regulating glial polarization

J **a, L Yang, C Huang, S Deng, Z Yang, Y Zhang… - Marine Drugs, 2023 - mdpi.com
Neuroinflammation induced by microglial and astrocyte polarizations may contribute to
neurodegeneration and cognitive impairment. Omega (n)-3 polyunsaturated fatty acids …

Systems biology–based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma

L Huang, S Garrett Injac, K Cui, F Braun, Q Lin… - Science translational …, 2018 - science.org
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Although
outcomes have improved in recent decades, new treatments are still needed to improve …

A Dichotomous role for FABP7 in sleep and Alzheimer's disease pathogenesis: a hypothesis

H Needham, G Torpey, CC Flores, CJ Davis… - Frontiers in …, 2022 - frontiersin.org
Fatty acid binding proteins (FABPs) are a family of intracellular lipid chaperone proteins
known to play critical roles in the regulation of fatty acid uptake and transport as well as …

Hypothyroidism induces interleukin-1-dependent autophagy mechanism as a key mediator of hippocampal neuronal apoptosis and cognitive decline in postnatal rats

J Mishra, J Vishwakarma, R Malik, K Gupta… - Molecular …, 2021 - Springer
Thyroid hormone (TH) is essential for brain development, and hypothyroidism induces
cognitive deficits in children and young adults. However, the participating mechanisms …