Mutations in KRAS are among the most frequent aberrations in cancer, including colon
cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule …

Simple Summary Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary
liver cancer leading to death in 10–15% of cases. In recent years, the iCCA worldwide …

BRAF V600E and KRAS mutations that occur in colorectal cancer (CRC) define a
subpopulation of patients with an inferior prognosis. Recently, the first BRAF V600E …

Background: The significance of Kirsten rat sarcoma viral oncogene (KRAS) mutation in
colorectal cancer (CRC) is well established; yet, its association with KRAS expression and …

Background: Due to high invasiveness and heterogeneity, the morbidity and mortality of
intrahepatic cholangiocarcinoma (ICC) remain unsatisfied. Recently, the exploration of …

In recent years, precision medicine has taken an increasing place in various branches of
medical oncology, including colorectal cancer. Among the potentially relevant mutations for …

The aim of the present study was to determine Kirsten Ras sarcoma virus (KRAS) mutations
and the associations of KRAS mutations with clinicopathological features and treatment …

Colorectal cancer poses a significant global health challenge, with a considerable
proportion arising from colon adenomas. Understanding the molecules involved in the …

Clinical practice guidelines have been developed to optimize oncologic care and outcomes
for patients with colorectal cancer (CRC). Prognostication relies heavily on the universally …

Clinical trial matches are displayed based upon somatic variant detection and patient
demographic and diagnostic information provided on the test requisition form. Trials are …