S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain
of cysteine, has emerged as an important mechanism for dynamic, post-translational …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that
this gaseous molecule is involved in the regulation of the cardiovascular, immune and …

In the past, reactive oxygen and nitrogen species (RONS) were shown to cause oxidative
damage to biomolecules, contributing to the development of a variety of diseases. However …

Exposure of cells to sublethal oxidative stress results in the modulation of various signaling
pathways. Oxidants can activate and inactivate transcription factors, membrane channels …

Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity,
translocating to the nucleus during apoptosis. Here we report a signalling pathway in which …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from
prokaryotes to mammals have evolved with an elaborate and redundant complement of …

Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on
cellular signal transduction and accumulating evidence indicates important roles for S …