Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …

Angiogenesis and metastasis are well recognized as processes fundamental to the
development of malignancy. Both processes involve the coordination of multiple cellular and …

Abstract The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family,
was initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a …

Autoregulatory domains found within kinases may provide more unique targets for chemical
inhibitors than the conserved ATP-binding pocket targeted by most inhibitors. The kinase …

Paks (p21‐activated kinases) are effectors for the small GTPases Cdc42 (cell division cycle
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …

Transformation of a normal cell to a cancer cell is caused by mutations in genes that
regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and …

MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-
specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 …

Some of the characteristics of cancer cells are high rates of cell proliferation, cell survival,
and the ability to invade surrounding tissue. The cytoskeleton has an essential role in these …

The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …