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Targeting rac and Cdc42 GTPases in cancer
Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …
are implicated in epithelial to mesenchymal transition, cell-cycle progression …
PAK signalling during the development and progression of cancer
Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis
Angiogenesis and metastasis are well recognized as processes fundamental to the
development of malignancy. Both processes involve the coordination of multiple cellular and …
development of malignancy. Both processes involve the coordination of multiple cellular and …
PAK signaling in cancer
Transformation of a normal cell to a cancer cell is caused by mutations in genes that
regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and …
regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and …
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
SW Deacon, A Beeser, JA Fukui, UEE Rennefahrt… - Chemistry & biology, 2008 - cell.com
Autoregulatory domains found within kinases may provide more unique targets for chemical
inhibitors than the conserved ATP-binding pocket targeted by most inhibitors. The kinase …
inhibitors than the conserved ATP-binding pocket targeted by most inhibitors. The kinase …
P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer
The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family, was
initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a …
initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a …
A tale of two Paks
Paks (p21‐activated kinases) are effectors for the small GTPases Cdc42 (cell division cycle
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …
Pak protein kinases and their role in cancer
Some of the characteristics of cancer cells are high rates of cell proliferation, cell survival,
and the ability to invade surrounding tissue. The cytoskeleton has an essential role in these …
and the ability to invade surrounding tissue. The cytoskeleton has an essential role in these …
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions
MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-
specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 …
specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 …
Pharmacological targeting of endoplasmic reticulum stress signaling in cancer
AH Schönthal - Biochemical pharmacology, 2013 - Elsevier
The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …